Erratum: T-helper Type 2–driven Inflammation Defines Major Subphenotypes of Asthma
نویسندگان
چکیده
منابع مشابه
Induction of ocular inflammation by T-helper lymphocytes type 2.
PURPOSE Sight-damaging ocular inflammation is often mediated by T-helper (Th) lymphocytes. The population of Th cells is divided into two major subsets, designated Th1 and Th2, that differ by their cytokine production and biological activities. In the present study, the capacity of Th1 and Th2 cells to induce ocular inflammation was examined. METHODS Ocular inflammation was induced in transge...
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Childhood asthma is strongly associated with the development of atopy and T helper type 2 (Th2)-driven allergic airway inflammation (Sly et al., 2008; Holt and Sly, 2012). However, the mechanisms involved in the induction of a Th2-biased immunologic response are poorly understood. Moreover, the cause-and-effect relationship between inflammation, airway remodeling and airway hyperresponsiveness ...
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BACKGROUND Major surgery is known to suppress T-cell function; however, its differential effects on the production of helper T-cell type 1 (T(H)1) and type 2 (T(H)2) cytokines remains unknown. OBJECTIVE To measure the production patterns of T(H)1 (interleukin 2 [IL-2] and interferon gamma) and T(H)2 (IL-4 and IL-10) cytokines following major surgery. DESIGN, SETTING, AND PATIENTS A cohort s...
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Objective(s):Pentoxifylline is an immunomodulatory and anti-inflammatory agent and is used in vascular disorders. It has been shown that pentoxifylline inhibits proinflammatory [d1] cytokines production. The purpose of this study was to investigate the therapeutic effects of pentoxifylline on the treatment of autoimmune diabetes in mice. Materials and Methods: Diabetes was induced by multiple l...
متن کاملt-helper cell type-1 transcription factor t-bet is down-regulated in type 1 diabetes
t cells have been identified as key players in the pathogenesis of type 1 diabetes. however, the exact role of t-cell subpopulations in this pathway is presently unknown. the purpose of this study was to assess the expression pattern of two lineage-specifying transcription factors gata - 3 and t - bet , which are important in t helper type 1 (th1) and th2 cell development , respectively. gene e...
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ژورنال
عنوان ژورنال: American Journal of Respiratory and Critical Care Medicine
سال: 2009
ISSN: 1073-449X,1535-4970
DOI: 10.1164/ajrccm.180.8.796